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目前在我国对于心血管疾病的无创性诊断及治疗后观察主要依赖病史、心电图变化及心肌坏死标记物如CK-MB、cTnT、cTnI等,很少重视神经-体液因素的作用,而血浆脑钠肽(BNP)是近年来研究较多的神经体液因子之一。上述的心肌坏死标记物仅在心肌有不可逆性损伤时才释放,但BNP在心肌缺血时就升高。在识别左室重构并予以充分治疗和预防其进展方面具有重要的临床价值。本文就该方面的研究概况作一简要的综述。
Currently in China for non-invasive diagnosis and treatment of cardiovascular disease mainly depends on history, ECG changes and myocardial necrosis markers such as CK-MB, cTnT, cTnI, little emphasis on neuro-humoral factors, and plasma brain natriuretic peptide Peptide (BNP) is one of the most studied neurohumoral factors in recent years. Myocardial necrosis markers described above are only released when the myocardium has irreversible damage, but BNP is elevated during myocardial ischemia. It has important clinical value in identifying left ventricular remodeling and providing adequate treatment and prevention of its progression. This article gives a brief overview of the research in this area.