【摘 要】
：
目的 探讨小儿支气管哮喘合并肺炎支原体(MP)感染的体液免疫与细胞免疫功能指标水平的变化,为其临床诊断与防治提供指导.方法 选取苏州市吴江区儿童医院自2019年12月至2021年4月收治的120例支气管哮喘患儿作为观察组,按照血浆MP抗体(MP-IgM)表达水平分为MP-IgM阳性组(67例)和MP-IgM阴性组(53例),另选取同期行健康体检的儿童60例作为对照组,开展前瞻性研究.对比对照组和观察组研究对象的MP-IgM阳性组和MP-IgM阴性组患儿免疫球蛋白水平、T淋巴细胞亚群水平及1型辅助性T细胞/
【机 构】
：
苏州市吴江区儿童医院儿内科,江苏 苏州 215200
论文部分内容阅读
目的 探讨小儿支气管哮喘合并肺炎支原体(MP)感染的体液免疫与细胞免疫功能指标水平的变化,为其临床诊断与防治提供指导.方法 选取苏州市吴江区儿童医院自2019年12月至2021年4月收治的120例支气管哮喘患儿作为观察组,按照血浆MP抗体(MP-IgM)表达水平分为MP-IgM阳性组(67例)和MP-IgM阴性组(53例),另选取同期行健康体检的儿童60例作为对照组,开展前瞻性研究.对比对照组和观察组研究对象的MP-IgM阳性组和MP-IgM阴性组患儿免疫球蛋白水平、T淋巴细胞亚群水平及1型辅助性T细胞/2型辅助性T细胞(Th1/Th2)比值.结果 观察组患儿血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)水平均显著高于对照组;MP-IgM阳性组显著高于MP-IgM阴性组;观察组患儿CD3+、CD4+百分比、CD4+/CD8+比值、Th1/Th2比值均显著低于对照组;且MP-IgM阳性组显著低于MP-IgM阴性组(均P<0.05).结论 支气管哮喘患儿多存在着免疫调节功能紊乱的表现,其中免疫球蛋白呈现出了异常升高的趋势,T淋巴细胞活化功能减弱,细胞免疫功能低下,且这种表现在合并MP感染患儿中更加显著.
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