论文部分内容阅读
肾性贫血的主要原因是促红细胞生成素的相对不足。此外,潴留的毒性代谢产物抑制骨髓的造血功能即血液中存在红细胞生成抑制因子,红细胞的破坏加速及小量出血亦与肾性贫血的发生有关。尿毒症患者长期食欲不振,营养物质(蛋白质、铁、维生素及叶酸等)的摄入不足或铝中毒均可使贫血加重。1 促红细胞生成素与肾性贫血肾性贫血治疗的重大进展是应用基因重组技术人工合成促红细胞生成素(recombinant human eryth-ropoietin)(简称促红素)的成功。促红素是一种涎糖蛋白,由165个氨基酸组成多肽,分子量30400。健康人每天合成促红素2～3 u/kg,其中90％以上在肾皮质生成,其余部分由肝脏合成。在肾脏及肝脏中均没有促红素的储备,当机体需要增力时可通过合成增多
Renal anemia is mainly due to the relative lack of erythropoietin. In addition, the retention of toxic metabolites inhibit the hematopoietic function of the bone marrow that the presence of erythropoietic inhibitory factor in the blood, accelerated destruction of red blood cells and a small amount of bleeding also related to the occurrence of renal anemia. Long-term loss of appetite in patients with uremia, nutritional deficiencies (protein, iron, vitamins and folic acid, etc.) or aluminum poisoning can make anemia worse. A major advance in the treatment of erythropoietin and renal anemia with renal anemia is the success of artificially synthesizing recombinant human erythroproietin (PRH) using gene recombination techniques. Erythropoietin is a salivary glycoprotein consisting of 165 amino acids with a molecular weight of 30,400. Healthy people daily synthesis of erythropoietin 2 ~ 3 u / kg, of which more than 90% of the formation of renal cortex, and the rest by the liver synthesis. In the kidneys and liver are no erythropoietin reserves, when the body needs to increase power through the synthesis of increased