蔡氏等的研究表明,平原条件下国外引进繁殖“缺氧敏感大鼠”(Hilltop SD,简作HT)的肺动脉压比国内常用的实验大鼠(Wistar简作W)高,低压舱内模拟5,000米高原缺氧,HT大鼠肺动脉压升高的程度较W大鼠明显。为探讨HT大鼠对缺氧敏感的生物学基础,我们应用放射性配基结合试验检测了平原对照及模拟5,000米高原缺氧15天的HT及W两种不同大鼠心,肺组织膜制备肾上腺素类受体反应性(Kd及Bmax)的变化,并进行 The study of Chua et al. Showed that the pulmonary arterial pressure introduced and propagated “Hilltop SD” in foreign countries under high altitude was higher than that of the commonly used experimental rats (Wistar) Hypoxic hypobaric rice, HT rat pulmonary artery pressure increased more significantly than the W rats. To investigate the biological basis of hypoxia susceptibility in HT rats, we used radioligand binding assay to test placental control and simulate hypoxia in 5,000-meter plateaus for 15 days in HT and W different rat hearts and lung tissue to prepare adrenal glands Receptor receptor reactivity (Kd and Bmax) changes, and carried out