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目的观察血必净注射液治疗重症肺炎患者的临床疗效。方法选取2014年8月—2015年10月解放军第474医院收治的重症肺炎患者97例,根据治疗方式不同分为常规治疗组45例和联合治疗组52例。常规治疗组患者采用常规治疗方案以及对症治疗,联合治疗组患者常规治疗组基础上给予血必净注射液;两组患者均连续治疗2周。比较两组患者临床疗效、治疗前后肺功能指标及血清炎性因子水平、不良反应发生情况。结果联合治疗组患者临床疗效优于常规治疗组(P<0.05)。治疗前,两组患者6分钟步行距离(6MWD)、用力肺活量(FVC)、第1秒用力呼气容积(FEV_1)、FEV_1/FVC、最大呼气中期流速(MMEF)及最高呼气流速(PEF)比较,差异无统计学意义(P>0.05);治疗后联合治疗组患者6MWD长于常规治疗组,FVC、FEV_1、FEV_1/FVC、MMEF及PEF均高于常规治疗组(P<0.05)。治疗前两组患者血清白介素6(IL-6)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,联合治疗组患者血清IL-6、hs-CRP和TNF-α水平低于常规治疗组(P<0.05)。两组患者治疗期间均未发生明显肝肾功能损伤,联合治疗组仅有1例患者出现胃肠道反应。结论血必净注射液治疗重症肺炎的临床疗效确切,可有效改善患者肺功能,降低血清炎性因子水平,且安全性较高。
Objective To observe the clinical effect of Xuebijing injection in patients with severe pneumonia. Methods From August 2014 to October 2015, 97 patients with severe pneumonia admitted to the 474th People’s Liberation Army were divided into 45 cases in the conventional treatment group and 52 cases in the combined treatment group according to the different treatment methods. Conventional treatment group patients with conventional treatment and symptomatic treatment, combined treatment group patients given routine treatment group Xuebijing injection; two groups of patients were treated for 2 weeks. The clinical curative effect was compared between the two groups, before and after treatment of lung function index and serum levels of inflammatory factors, the occurrence of adverse reactions. Results The clinical efficacy of the combined treatment group was better than that of the conventional treatment group (P <0.05). Before treatment, 6MWD, FVC, FEV_1, FEV_1 / FVC, MMEF, and PEF (P> 0.05). Compared with the conventional treatment group, the 6MWD in the combined treatment group was longer than that in the conventional treatment group. The FVC, FEV 1, FEV 1 / FVC, MMEF and PEF in the combined treatment group were significantly higher than those in the conventional treatment group (P <0.05). The levels of serum interleukin 6 (IL-6), hs-CRP and TNF-α in the two groups before treatment were not significantly different (P> 0.05). After treatment The levels of IL-6, hs-CRP and TNF-α in the combined treatment group were lower than those in the conventional treatment group (P <0.05). Two groups of patients during treatment did not occur significant liver and kidney dysfunction, combined treatment group, only 1 patient gastrointestinal reactions. Conclusion Xuebijing injection for severe pneumonia clinical curative effect is exact, can effectively improve lung function, reduce serum levels of inflammatory cytokines, and high safety.