目的探讨阴道内酸性环境与白色念珠菌性外阴阴道炎的相关性。方法分别对2009年6月至2010年3月妇科门诊的单纯性外阴阴道假丝酵母菌病(SVVC)患者进行阴道菌株分离、鉴定,获得白色念珠菌96株。检测不同pH值环境下菌株对硝酸咪康唑与克霉唑的药物敏感性,并观察相关性。结果在pH值偏酸性的环境下,两种唑类药物的MIC均有不同程度的降低,对白色念珠菌抑菌效果更强。结论维持阴道内酸性环境能更有效地治疗白色念珠菌性外阴阴道炎。 Objective To investigate the relationship between intravaginal acidic environment and Candida albicans vulvovaginitis. Methods A total of 96 strains of Candida albicans were isolated and identified from patients with simple vulvovaginal candidiasis (SVVC) in gynecology clinic from June 2009 to March 2010. The drug susceptibility of strains to miconazole nitrate and clotrimazole was tested under different pH values ​​and the correlation was observed. Results Under the acidic pH condition, the MICs of both azole drugs decreased to some extent and the antibacterial activity against Candida albicans was stronger. Conclusions Maintaining vaginal acidic environment can treat C. albicans vulvovaginitis more effectively.