论文部分内容阅读
目的 :研究乳腺癌新生间质血管密度、肿瘤细胞增殖活性与临床指标间的相互关系 ,为临床判定肿瘤转移及预后提供新的指标。方法 :采用免疫组化方法对 31例乳腺癌进行了间质血管密度、肿瘤细胞增殖活性的检测。结果 :乳腺癌间质血管密度在淋巴结转移阳性者与淋巴结转移阴性者之间具有显著性差异 (P<0 .0 1 ) ;肿瘤细胞增殖活性随乳腺癌组织学级别的增高而增加 ;乳腺癌肿瘤细胞增殖活性随间质血管密度的增加而具有增高的趋势。结论 :乳腺癌间质血管密度及细胞增殖活性可以成为临床判定转移和预后的指标
OBJECTIVE: To study the relationship between interstitial vascular density (BMD), tumor cell proliferative activity and clinicopathological parameters in breast neoplasms, and to provide a new index for clinical judgment of tumor metastasis and prognosis. Methods: Immunohistochemistry was used to detect the density of interstitial blood vessels and the proliferation of tumor cells in 31 cases of breast cancer. Results: The density of interstitial blood vessels in breast cancer was significantly different between those with positive lymph node metastasis and those with negative lymph node metastasis (P <0.01). The proliferation of breast cancer cells increased with the histological grade of breast cancer. The breast cancer Tumor cell proliferative activity increased with the increase of interstitial vascular density. Conclusion: The density and cell proliferative activity of interstitial blood vessels in breast cancer can be indicators of clinical metastasis and prognosis