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目的探讨高血压家族史和肥胖对高血压患病是否存在交互作用。方法以青岛地区2006年和2009年调查的10 224名35~74岁社区居民为研究对象,将现场调查中发现的4 812例高血压患者纳为病例组,以同期调查的5 412名血压正常者为对照组。采用单因素及多因素Logistic回归分析高血压患病的危险因素,运用相加模型分析高血压家族史和肥胖是否对高血压患病存在交互作用,当OR(AB)>OR(A)+OR(B)-1时,说明A、B两因素存在正交互作用。结果用多因素非条件Logistic回归调整年龄、性别、文化程度、经济收入等因素后,高血压家族史与肥胖同时存在时,高血压患病的协同效应指数为1.20,归因交互效应为1.45,归因交互效应百分比为33.0%,纯因子间归因交互效应百分比为42.7%。结论高血压家族史和肥胖同时存在时可增加居民高血压患病的风险性。
Objective To investigate whether there is an interaction between family history of hypertension and obesity on the prevalence of hypertension. Methods A total of 4,812 hypertension patients found in the field survey were enrolled in this study from 10 224 community residents aged from 35 to 74 who were investigated in Qingdao in 2006 and 2009. In the same period, 5 412 normal blood pressure For the control group. Univariate and multivariate logistic regression analysis was used to analyze the risk factors of hypertension. The additive model was used to analyze whether family history of hypertension and obesity had interaction with hypertension. When OR (AB)> OR (A) + OR (B) -1, indicating that A, B two factors exist orthogonal interaction. Results After adjusting for factors such as age, gender, educational level and economic income by multivariate non-conditional Logistic regression, the synergistic effect index of hypertension was 1.20 and the attribution interaction effect was 1.45 when both family history of hypertension and obesity existed. The percentage of attributional interaction was 33.0% and the percentage of attributional interaction of pure factors was 42.7%. Conclusion The family history of hypertension and obesity may increase the risk of hypertension in residents.