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目的观察早期胃肠内营养支持对重型颅脑损伤患者免疫功能及预后的影响。方法对86例重型颅脑损伤术后患者随机分为实验组和对照组,实验组于入院24h内开始给予能全力,对照组采取推注法经胃管管饲普通流质饮食,治疗28d后检测T淋巴细胞及其亚群(CD4、CD8、CD4/CD8)和两组血清白蛋白(ALB)、空腹血糖(FBG)、氮平衡(NB)的变化及并发症的发生情况。结果实验组并发症的发生率显著低于对照组,实验组CD4、CD4/CD8比值、血清白蛋白、空腹血糖、氮平衡均优于对照组(P<0.05)。结论早期胃肠内营养支持能有效地纠正重型颅脑损伤后的低蛋白血症及负氮平衡,改善患者的免疫功能,降低并发症的发生率。
Objective To observe the effects of early gastrointestinal nutrition support on immune function and prognosis in patients with severe craniocerebral injury. Methods Eighty-six patients with severe craniocerebral injury were randomly divided into experimental group and control group. The experimental group began to give full play within 24 hours after admission, while the control group received normal liquid diet by bolus injection. After 28 days of treatment, T lymphocytes and their subsets (CD4, CD8, CD4 / CD8), serum albumin (ALB), fasting blood glucose (FBG), nitrogen balance (NB) and the incidence of complications. Results The incidence of complications in the experimental group was significantly lower than that in the control group. The ratio of CD4, CD4 / CD8, serum albumin, fasting blood glucose and nitrogen balance in the experimental group were better than those in the control group (P <0.05). Conclusion Early gastrointestinal nutrition support can effectively correct hypoalbuminemia and negative nitrogen balance after severe craniocerebral injury, improve patients’ immune function and reduce the incidence of complications.