论文部分内容阅读
光疗是通过光线(通常用420～470nm波长的蓝光末端光谱)照射,加速氧化分解游离胆红素。光减少血清胆红素水平通过两个基本机制:光同分异构化和感光氧化。在光同分异构化中,胆红素从一个相对不可溶状态(胆红素Ⅸ—αZ,Z)转变成水溶性同分异构体(光胆红素),有胆红素Ⅸ—αE、Z、胆红素Ⅸ—αE,E和胆红素Ⅸ—αZ,E,Z,E形式是主要的同分异构体。胆红素的光氧化作用导致其水解成水溶性单、双和三吡咯,它们无神经毒,能通过胆汁或尿排泄。近年来又推荐用绿色荧光灯照射,绿光更易通过皮肤、效果略优于蓝光。而白光退黄效果较蓝光差10％。光疗可降低胆红素峰值20～25％,一般
Phototherapy is through the light (usually with a wavelength of 420 ~ 470nm blue end spectrum) irradiation, accelerated oxidation and decomposition of free bilirubin. Light reduces serum bilirubin levels through two basic mechanisms: photoisomerization and photooxidation. In photoisomerization, bilirubin is converted from a relatively insoluble state (bilirubin IX-aZ, Z) to a water-soluble isomer (bilirubin) with bilirubin IX- αE, Z, bilirubin IX-αE, E and bilirubin IX-αZ, E, Z, E forms are the major isomers. The photooxidation of bilirubin causes its hydrolysis to water-soluble mono-, di- and tri-pyrrole, which are neurotoxic and can be excreted by bile or urine. In recent years it is recommended to use green fluorescent light irradiation, green light more easily through the skin, the effect is slightly better than the blue light. The white light yellow effect worse than the blue 10%. Light therapy can reduce the peak bilirubin 20 ~ 25%, in general