【摘 要】
：
In order to understand why CD2 has a dual action of transduction of activation or apoptosis signals in T cells under different experimental conditions, we emplo
【机 构】
：
State Key Laboratory of Experimental Hematology,State Key Laboratory of Medical Molecular Biology
【基金项目】
：
国家重点基础研究发展计划(973计划);卫生部资助项目;国家自然科学基金
论文部分内容阅读
In order to understand why CD2 has a dual action of transduction of activation or apoptosis signals in T cells under different experimental conditions, we employed a yeast two-hybrid system to look for a binding protein of the cytoplasmic domain of CD2 which may be involved in this issue. A human T cell cDNA library was screened by a cDNA encoding the cytoplasmic domain of CD2 (Thr211-Gln336). The specificity of protein-protein interaction was verified by co-immunoprecipitation. The binding protein obtained, designated CD2cBP, was found to be homologous to v-fos transformation effector protein (Fte-1). As Fte-1 plays a role in cell transformation, growth, protein synthesis and protein-import into mitochondria, this result suggests that CD2cBP may be putatively involved in CD2-mediated signaling.
其他文献
A method using synchrotron radiation X-ray fluorescence analysis to in situ determine trace elements during protein electrophoretically separating process was e
当今世界最主要的环境问题就是气候问题。由于世界各国在发展经济的同时，没有从根本上解决环境污染问题，导致环境问题日益突出。当今世界面临着全球气候变暖、臭氧层破坏和损耗
随着我国矿山开采技术的快速发展，矿山在生产过程中会给矿区及周围自然环境、地质环境等各个方面带来一定影响和破坏。如何在矿山开采过程中对矿山地质环境进行保护与治理，已经
The assembly of microtubules is essential for physiological functions of microtubules. Addition of microtubule-stabilizing reagents or microtubule "seeds" is us
It was identified that there were 4 St chromosomes derived from Th.intermedium in common wheat-Th.intermedium alien additional line TAI-27 by in situ hybridizat
贵州省赫章县兴发乡中寨村野里坝组，缺水人口1000人，缺水情况较为严重。特别是在干旱年，供水水量不足的问题更加明显，大大影响了居民日常生活，制约了村镇建设发展步伐。因此，为该区
A new evolutionary theory which is able to unite the present evolutionary debates is deduced mathematically from the principle of entropy amplification.It sugge
本文主要集中讨论了畜牧生产过程中可能造成的环境污染问题，同时，针对畜牧生产的环境污染问题进行了分析，提出了有针对性的治理对策，以期能够有效的避免畜牧生产对环境造成的污染
The 660 bp region between nodD3 P1 promoter and the following coding region of Rhizobium meliloti has been studied.This region is designated "downstream sequenc
The upstream regulatory region of a seed-specific gene was isolated from the genomic DNA of Brassica napus by PCR amplification. The cloned fragment contained 1