聚合硫酸铁与碱式氯化铝两种净水剂对大、小白鼠影响的实验研究

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本实验通过测定分析两种净水剂产品聚合硫酸铁和碱式氯化铝内有毒金属含量并以实验动物论证与机体健康的关系。1、毒性蓄积实验:选用NIH小白鼠30只,体重18~20g,以聚合硫酸铁的半致死量(LD50)重变小剂量给药,结果具习惯性。2、慢性毒性实验:选用Wistar大鼠24只,雌雄各半,随机分二组,每组12只。分别饮用含聚合硫酸铁(A组)、碱式氯化铝(B组)做净化剂的同批自来水,常规饲料喂养四个半月。观察指标:血常规、生化学检查、肝、肾光镜、电镜形态学观察及有关酶活性检查。结果,B组大鼠的肝细菌、肾小管上皮细胞线粒体肿胀、脊断裂、有小空泡、空泡样变化。ALT(谷丙转氨酶)比A组明显升高(P<0.01),SDH(琥珀酸脱氢酶)、ATPase(三磷酸腺苷酶)的活性有所减弱、LDH(乳酸脱氢酶)、ACP(酸性磷酸酶)活性有所增强。A组各结果正常。提示:大鼠长期饮用以聚合硫酸铁为净水剂的自来水对其健康无影响,长期饮用以碱式氯化铝为净水剂的自来水对其肝、肾有一定的影响。 In this experiment, the content of toxic metals in polymerized ferric sulfate and basic aluminum chloride of two kinds of purifying agent products was analyzed and analyzed, and the relationship between them and body health was demonstrated by experimental animals. 1, Toxicity accumulation experiment: 30 NIH mice were selected and their body weight was 18 ~ 20g. The LD50 of the polymeric ferric sulfate was used in a small dose, and the result was habitual. 2, chronic toxicity test: 24 Wistar rats were selected, male and female, were randomly divided into two groups of 12 rats. Separately drinking the same batch of tap water containing polyferric sulfate (group A) and basic aluminum chloride (group B) as the decontamination agent, the normal feed was fed for four and a half months. Observations: blood, biochemical tests, liver and kidney light microscopy, electron microscopy morphology and related enzyme activity check. Results, liver tissue of rats in Group B, tubular epithelial cells mitochondria swelling, spinal rupture, small vacuoles, vacuolar changes. ALT (alanine aminotransferase) was significantly higher than that of A group (P <0.01), while the activity of SDH (succinate dehydrogenase) and ATPase (adenosine triphosphate) were weakened. The activities of LDH (lactate dehydrogenase), ACP Acid phosphatase) activity has been enhanced. A group of the results were normal. Tip: Long-term drinking water to polymerize ferric sulfate water purifier has no effect on their health, long-term drinking water with basic aluminum chloride as tap water on the liver and kidney have a certain impact.
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