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采用自身单盲、随机区组设计方差分析法,观察42例低氧血的慢性阻塞性肺病患者分别单剂量雾化吸入硫酸阿托品、氯喘通及硝苯吡啶后,其血气变化情况。结果:吸入阿托品后,30min内的每个时间的血气变化影响甚微;相反,氯喘通及硝苯吡啶均使血氧分压降低(分别为P<0.01和0.05)。结果说明,对于慢支、肺气肿所致的低氧血患者,在不加重全身性低血氧的影响方面,阿托品比其它两种药物更可取。
A single blind, randomized block design analysis of variance was used to observe the changes of blood gas in 42 patients with chronic obstructive pulmonary disease with hypoxemia after single-dose inhalation of atropine sulfate, chlortetracycline and nifedipine respectively. RESULTS: After inhaled atropine, blood gas changes had little effect at each time within 30 min. On the contrary, both chlorothalonil and nifedipine decreased the partial pressure of oxygen (P <0.01 and 0.05, respectively). The results show that, for chronic bronchitis, emphysema-induced hypoxemic patients, do not aggravate the impact of systemic hypoxemia, atropine is preferable to the other two drugs.