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1963年苏联学者Abelev等首先在移植性肝癌小鼠的血清中发现甲胎蛋白(α-Fet-oprotein AFP)。翌年,Tatarinov报道自原发性肝细胞癌(简称肝癌)患者血清中检出AFP,从而AFP的研究普遍展开。
In 1963 Soviet scholar Abelev et al. first discovered alpha-Fet-oprotein AFP in the serum of transplanted liver cancer mice. In the following year, Tatarinov reported that AFP was detected in the serum of patients with primary hepatocellular carcinoma (abbreviated as hepatocellular carcinoma), and the AFP study was generally carried out.