论文部分内容阅读
ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠预免疫２周后，采用由腹腔逐渐过渡至静脉的方法，每日注射阳离子化牛血清白蛋白（ＣＢＳＡ）。结果：静脉注射ＣＢＳＡ２周后，荧光显微镜观察显示ＩｇＧ沿肾小球毛细血管壁呈颗粒状沉积，光镜下可见有新月体形成，电镜下可见大量上皮下电子致密沉积物；４周后，上皮下电子致密沉积物融合成大片状；６周后，较多大鼠出现肾小球硬化。
After 2 weeks of pre-immunization in Sprague-Dawley rats, cationized bovine serum albumin (C-BSA) was injected daily by a gradual transition from the abdominal cavity to the vein. RESULTS: After 2 weeks of intravenous injection of C-BSA, fluorescence microscopy showed that IgG was deposited in a granular form along the glomerular capillary wall. There was crescent formation under light microscopy. A large number of subepithelial electron dense deposits were seen under electron microscope; 4 weeks Afterwards, the electron-dense deposits under the epithelium fuse into large pieces; after 6 weeks, more rats developed glomerulosclerosis.