论文部分内容阅读
绵羊红细胞受体(ER)作为T细胞的表面标志,已有十余年历史,但对其特异性始终存在着怀疑。如有些E花环阳性(E~+)单核的细胞具有自然杀伤活性,同时缺乏T细胞的其他表面标志和T细胞的功能活性。ER亦可出现于异常B细胞和单核细胞。近来有人报道,毛细胞白血病及慢性淋巴细胞白血病的异常B细胞与有丝分裂原和自身或同种T细胞一起培养,可诱导表达内生性ER。本文作者将正常人B细胞经适宜培养,亦诱导出内生性ER,并对ER作为T细胞表面标志的特异性进一步置疑。
Sheep red blood cell receptor (ER) as a T cell surface marker, more than 10 years of history, but its specificity is always in doubt. Some E-rosette-positive (E ~ +) mononuclear cells have natural killer activity, while lacking other surface markers of T cells and functional activity of T cells. ER can also occur in abnormal B cells and monocytes. Recently, it has been reported that abnormal B cells of hairy cell leukemia and chronic lymphocytic leukemia are cultured with mitogens and autologous or allogeneic T cells to induce the expression of endogenous ER. The author of the normal B cells by appropriate culture, but also induced endogenous ER, and ER as a T cell surface markers further suspicion.