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普鲁卡因(奴佛卡因鹽基)油注射液自1952年始广泛用于临床,作为持久性麻醉剂和镇痛剂,常用濃度为2—10%,止痛有效时間据报导为4—20天。該注射液制造要点之一是由鹽酸普鲁卡因加硷制得二水合普魯卡因,后者脫水后即得无水普魯卡因。无水普魯卡因溶于注射用油中,經灭菌制剂的操作步驟就可制得普魯卡因油注射液。制造过程一般采用本刊1953年6期224頁所介紹的方法。制無水普魯卡因的关鍵在于脫水完全。如脫水不完全則含水的普鲁卡因不溶于油中而大大減弱麻醉和
Procaine (novocaine base) oil injection has been widely used in clinical practice since 1952. As a permanent anesthetic and analgesic, the usual concentration is 2-10%, and the effective time for analgesia is reported to be 4-20. day. One of the key points for the production of this injection is procaine dihydrate, which is obtained by adding procaine hydrochloride. When the latter is dehydrated, anhydrous procaine is obtained. Anhydrous procaine is dissolved in the injection oil, and the procaine oil injection can be prepared through the procedure of the sterilization preparation. The manufacturing process generally adopts the method described in this publication, 1953, 6 224 pages. The key to producing anhydrous procaine is complete dehydration. If dehydration is not complete, water-containing procaine is insoluble in oil and greatly reduces anesthesia and