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人和动物的恶性肿瘤有无特异性抗原,是一个长期争论的问题。一般学者认为恶性肿瘤的抗原结构与正常组织有所不同(Green,1958;Zilber,1958;Black,1959)。至于这种差异的性质,则各人的看法不尽相同,有人认为当细胞变为恶性时就获得了特异性抗原(Zilber,1957;B等,1959),另一些人则认为肿瘤细胞没有特异性抗原,甚至失去了固有的组织抗原(Weiler,1959),还有人提出肿瘤细胞比正常细胞的抗原有增有减
It is a long-standing issue that human and animal malignancies have specific antigens. Scholars generally think that the antigenic structure of malignant tumors is different from that of normal tissues (Green, 1958; Zilber, 1958; Black, 1959). As for the nature of this difference, everyone disagrees. Some believe that specific antigens are acquired when the cell becomes malignant (Zilber, 1957; B et al., 1959), while others assume that the tumor cells are not specific Sexual antigens, and even the loss of innate tissue antigens (Weiler, 1959). Others have suggested that tumor cells have more or less antigens than normal cells