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目的:探讨黄体酮胶丸治疗黄体功能不全引起的复发性早期流产的临床效果。方法:将2014年1月-2015年6年我科诊治的黄体功能不全引起的复发性早期流产患者106例随机分为研究组与对照组各53例,对照组予HCG针剂和黄体酮针剂进行治疗,研究组予黄体酮胶丸治疗,比较两组治疗前及治疗1周后的血清孕酮值的改善情况、临床疗效及不良反应发生情况。结果:研究组与对照组治疗前的血清孕酮值无明显差异(70.2±10.1 ng/ml vs 70.6±9.5 ng/ml,P>0.05),研究组治疗1周后的血清孕酮值的改善情况明显优于对照组(88.6±9.3 ng/ml vs 81.4±10.2 ng/ml,P<0.05);研究组的总有效率明显高于对照组(90.6%vs 79.3%,P<0.05);研究组与对照组不良反应的发生情况无明显差异(5.7%vs 7.5%,P>0.05)。结论:与HCG针剂和黄体酮针剂治疗黄体功能不全引起的复发性早期流产相比,应用黄体酮胶丸治疗的临床疗效更好,且不增加不良反应,建议临床推广应用。
Objective: To investigate the clinical effect of progesterone capsules in the treatment of recurrent early abortion caused by luteal insufficiency. Methods: A total of 106 patients with recurrent early abortion caused by luteal insufficiency in our department from January 2014 to 2015 were randomly divided into study group (53 cases) and control group (53 cases). The control group received HCG injection and progesterone injection The treatment group and the study group were treated with progesterone capsules. The improvement of serum progesterone level, clinical efficacy and adverse reactions before and after treatment for 1 week were compared between the two groups. Results: There was no significant difference in the serum progesterone levels between the study group and the control group before treatment (70.2 ± 10.1 ng / ml vs 70.6 ± 9.5 ng / ml, P> 0.05) (88.6 ± 9.3 ng / ml vs 81.4 ± 10.2 ng / ml, P <0.05). The total effective rate in the study group was significantly higher than that in the control group (90.6% vs 79.3%, P <0.05) There was no significant difference in adverse reactions between the two groups (5.7% vs 7.5%, P> 0.05). CONCLUSION: Compared with HCG injection and progesterone injection in the treatment of recurrent early abortion caused by luteal insufficiency, the application of progesterone capsules has better clinical efficacy and no adverse reactions. Therefore, it is recommended for clinical application.