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目的:探讨哌拉西林/他唑巴坦致不良反应(ADR)的规律和特点,为临床用药提供参考。方法:对2002-2013年国内期刊发表的哌拉西林/他唑巴坦致ADR文献进行检索,并就收集到的23例ADR的相关情况进行统计和分析。结果:23例ADR患者年龄分布以老年人为主;发生时间最快为静脉滴注1滴时发生,最慢为连续用药19 d后;以过敏反应(过敏性休克和皮肤及其附件损害)最多,其次为血液系统损害。结论:临床应严格掌握哌拉西林/他唑巴坦适应证,实施个体化给药,同时密切关注患者情况,发生ADR及时处理,并上报ADR监测网。
Objective: To investigate the regularity and characteristics of piperacillin / tazobactam-induced adverse reactions (ADRs) and provide references for clinical use. Methods: The literature of ADR induced by piperacillin / tazobactam published in domestic journals from 2002 to 2013 was searched. The data of 23 cases of ADR were collected and analyzed. Results: The age distribution of 23 ADR patients was dominated by the elderly. The fastest onset time was 1 drop intravenously, the slowest was 19 d after the continuous administration. The most patients had anaphylactic reaction (anaphylactic shock and damage of the skin and their appendages) , Followed by blood system damage. Conclusion: Clinically, the indications of piperacillin / tazobactam should be strictly grasped, and individualized administration should be carried out. At the same time, the patient’s condition should be closely monitored. ADR should be promptly treated and reported to the ADR monitoring network.