目的分析内镜经鼻蝶窦入路切除垂体腺瘤术后的并发症。方法对40例内镜经鼻蝶窦入路切除垂体腺瘤手术并发症的临床资料进行回顾性分析。结果术中脑脊液鼻漏2例,经“三明治”修补后治愈;术后脑脊液鼻漏2例,经腰大池置管引流后治愈。术后出现暂时性尿崩4例,颅内感染1例,垂体分泌功能低下2例,蝶窦炎1例;经治疗后均好转。术后嗅觉障碍2例,经治疗后无好转。无死亡病例。结论术中规范精细操作、术后严密观察和积极有效处理并发症有助于提高内镜经鼻蝶垂体腺瘤切除手术效果。 Objective To analyze the postoperative complications of endoscopic transnasal sphenoid sinus surgery. Methods The clinical data of 40 cases with endoscopic transnasal sphenoid sinus resection for the complications of pituitary adenoma were analyzed retrospectively. Results The intraoperative cerebrospinal fluid rhinorrhea in 2 cases was cured after the “sandwich” repair; 2 cases of cerebrospinal fluid rhinorrhea, and was cured by drainage and drainage of the lumbar cistern. Postoperative transient diabetes insipidus in 4 cases, 1 case of intracranial infection, hypopituitarism in 2 cases, 1 case of sphenoid sinusitis; after treatment were improved. 2 cases of postoperative olfactory dysfunction, no improvement after treatment. No deaths. Conclusions Intraoperative standard fine operation, close observation after operation and active and effective treatment of complications are helpful to improve endoscopic transsphenoidal pituitary adenoma resection.