急性细菌性脑膜炎致死率较高,在幸存者中,永久性的听力丧失达10％。该作者通过实验建立了类似于人类脑膜炎源性迷路炎的动物模型,即感染3型肺炎链球菌致急性脑膜炎源性迷路炎的豚鼠,并对其发病机理、后遗症及迷路炎的治疗作了研究。在实验中使用不同剂量的细菌单位及生理盐水作豚鼠的鞘内注射。实验组共11只动物,对照组(即生理盐水组)2只动物。 Acute bacterial meningitis has a high fatality rate, with permanent hearing loss of 10% among survivors. The authors experimentally established an animal model similar to human meningitis-derived labyrinthitis that infects guinea pigs with acute meningitis-induced labyrinthitis caused by Streptococcus pneumoniae type 3, and treats its pathogenesis, sequelae, and labyrinthitis Study. In the experiment using different doses of bacterial units and saline for guinea pig intrathecal injection. A total of 11 experimental animals, control group (ie saline group) two animals.