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正畸牙移动是在机械力的作用下,通过对牙周膜产生牵张或压缩的力来引起牙周组织在生理限度内的组织改建,从而达到牙齿移动、矫治畸形的目的。由于没有明显的年龄限制,正畸矫治在全球范围已变得越来越普遍。因此,相关的研究也日益增多。牙齿移动的生物学基础是正畸力作用于牙周组织激活一系列信号转导通路,进而引起牙周膜的修复改建。为指导临床、加速正畸矫治疗程提供新的思路,本文综述了近年来有关正畸牙移动相关信号通路的研究进展。发现最新的研究集中在MAPK信号通路,Wnt/β-catenin信号通路,PI3K/AKt/m TOR信号通路,BMP-2信号通路,Caspase-3介导的凋亡通路较多。但是正畸牙移动引起的牙周组织改建是一个多种生物力学信号转导通路相互调节相互作用的过程,对于上述信号通路之间的相互关系还有待于我们更进一步的探索。
Orthodontic tooth movement is the role of mechanical force, through the periodontal ligament produce stretch or compression force to cause periodontal tissue within the physiological limits of the reorganization, so as to achieve the purpose of tooth movement, correction of deformity. Orthodontics has become more and more common worldwide on the absence of significant age limitations. Therefore, related research is also increasing. The biological basis of tooth movement is that orthodontic force acts on periodontal tissue to activate a series of signal transduction pathways, which in turn leads to the repair and reconstruction of periodontal ligament. In order to guide the clinical and accelerate the process of orthodontic treatment provides new ideas, this review summarizes recent years, the research progress of orthodontic tooth movement related signaling pathways. It is found that the latest research focuses on the MAPK signaling pathway, Wnt / β-catenin signaling pathway, PI3K / AKt / m TOR signaling pathway, BMP-2 signaling pathway, Caspase-3 mediated apoptosis pathway. However, orthodontic tooth movement caused by periodontal tissue remodeling is a variety of biomechanical signal transduction pathway mutual regulation interaction process, the relationship between the above signal path remains to be further explored.