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目的:对比吸入相同浓度七氟烷对发绀型及非发绀型先天性心脏病(先心病)患儿在诱导期不同时间点脑电双频指数(BIS)值的影响。方法:选择先心病患儿39例,其中发绀组19例(C组),非发绀组20例(NC组)。应用8%七氟烷诱导进入麻醉状态,记录维持七氟烷呼末浓度1.5MAC 5 min(T1)、10 min(T2)、气管插管后5 min(T3)和10 min(T4)的BIS值、平均动脉压(MAP)值和心率(HR)值。结果:发绀组T1点BIS值明显高于T2、T3、T4各点(P<0.05),非发绀组T1、T2、T3及T4各点BIS值比较差异无统计学意义。发绀组T1点BIS值明显高于非发绀组(P<0.05),而T2、T3、T4各点2组间BIS值差异无统计学意义。MAP值和HR值在组间和组内各点比较差异均无统计学意义。结论:麻醉诱导维持七氟烷呼末浓度1.5MAC,发绀型与非发绀型先心病患儿BIS值均能维持在适当的麻醉深度,但发绀型先心病患儿加深麻醉达到相同BIS值的时间较非发绀型患儿延迟。
Objective: To compare the effects of inhaling sevoflurane of the same concentration on bispectral index (BIS) at different time points in cyanotic and non-cyanotic children with congenital heart disease (CHD). Methods: Thirty-nine children with congenital heart disease were selected, including 19 cases of cyanotic group (C group) and 20 cases of non-cyanotic group (NC group). The rats were anesthetized with 8% sevoflurane, and the BIS was recorded after 5 min (T1), 10 min (T2), 5 min (T3) and 10 min Value, mean arterial pressure (MAP) value and heart rate (HR) value. Results: The BIS value of cyanotic group was significantly higher than that of T2, T3 and T4 (P <0.05). There was no significant difference in BIS between T1, T2, T3 and T4 in non-cyanotic group. The BIS value of T1 point in cyanotic group was significantly higher than that in non-cyanotic group (P <0.05), while there was no significant difference in BIS value between T2, T3 and T4 points. There was no significant difference in MAP and HR between the groups and among the groups. CONCLUSION: BIS value of sevoflurane in patients with cyanotic and non-cyanotic congenital heart disease can maintain a proper depth of anesthesia with anesthesia induction maintaining sevoflurane end-point concentration of 1.5MAC. However, children with cyanotic congenital heart disease have the same BIS value for deepening anesthesia Compared with non-cyanotic children delayed.