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在上消化道大量出血时,常应用甲氰咪胍治疗。甲氰咪胍的副作用较少,但如剂量过大,则可出现心肌病变和精神异常。由于甲氰咪胍系经肾脏排出,仅小部分在肝脏转变为氢甲基化合物和亚砜类,因此一般认为在肝脏病变时,药物应用的剂量不须减少。由于甲氛咪肌的排出主要和肾小球滤过率有关,过去文献均强调如血清肌醉值低于n伽mol/l,则药物即可应用正常剂量。作者等认为在肝脏病变时,如何应用甲氰咪肌,尚须进一步研究。作者将上消化道出血患者分为下列三组:(1)非肝硬化病例,血清肌醉值正常,共8例。(3)肝硬化,血清肌醉值正常,共8例。
In the upper gastrointestinal bleeding, often cimetidine treatment. Cimetidine side effects are less, but if the dose is too large, then there may be myocardial lesions and mental disorders. Since cimetidine is excreted by the kidneys, only a small portion is converted to methylol and sulfoxides in the liver, so it is generally accepted that there is no need to reduce the dose of drug used in liver lesions. Due to the release of a methylpigment muscle and glomerular filtration rate mainly related to the literature in the past are stressed that if the serum is less than n Gamma / l, then the drug can be applied to the normal dose. The authors believe that in the liver lesions, how to use methyl cyanogen muscle, still need further study. The authors divided the upper gastrointestinal bleeding patients into the following three groups: (1) non-cirrhotic cases, normal serum levels of drunkenness, a total of 8 cases. (3) cirrhosis, normal serum values, a total of 8 cases.