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目的 :检测血清TGF -α在肝癌临床的应用价值。方法 :采用放射免疫法检测 38例原发性肝癌、16例肝转移癌、2 0例肝硬化及 2 5例正常人的血清TGF -α含量 ,并与AFP值进行比较。数据用x±s表示 ,以正常人x± 2s作为上限计算TGF -α阳性率 ,以 4 0 0 μg/L为上限计算AFP阳性率。 结果 :肝硬化组与正常对照组血清TGF -α比较无显著性差异 (P >0 0 5 )。原发性肝癌组、肝转移组血清TGF -α水平显著高于正常对照组 (分别P <0 0 5、P <0 0 1) ;原发性肝癌Ⅲ期组血清TGF-α水平高于Ⅱ期 ,但无明显差别 (P >0 0 5 ) ;原发性肝癌组肝转移组血清TGF -α水平无显著性差异 (P >0 0 5 ) ;肝转移组血清TGF -α和AFP阳性率分别为 6 8 8%和 0 % ;原发性肝癌组血清TGF -α和AFP阳性率分别为 78 9%和 6 8 4 %。结论 :肝癌患者血清TGF -α明显升高 ,血清TGF -α检测有助于肝癌的诊断、鉴别诊断 ,效果优于AFP ,但对原发性肝癌临床分期意义不大
Objective: To detect the clinical value of serum TGF-α in hepatocellular carcinoma. Methods: The serum levels of TGF-α in 38 cases of primary hepatocellular carcinoma, 16 cases of hepatic metastases, 20 cases of liver cirrhosis and 25 normal individuals were detected by radioimmunoassay and compared with AFP values. The data were expressed as x ± s, the positive rate of TGF-α was calculated as the upper limit of normal ± x 2s, and the positive rate of AFP was calculated as the upper limit of 400 μg / L. Results: There was no significant difference in serum TGF-α between cirrhosis and normal controls (P> 0.05). The levels of serum TGF-α in primary liver cancer group and liver metastasis group were significantly higher than those in normal control group (P <0.05, P <0.01) (P> 0.05). There was no significant difference in the serum levels of TGF-α between the two groups (P> 0.05). The positive rates of TGF-α and AFP in the liver metastasis group Respectively, 68.8% and 0% respectively. The positive rates of TGF-α and AFP in patients with primary liver cancer were 78.9% and 68.4%, respectively. Conclusion: The serum level of TGF-α in patients with hepatocellular carcinoma is significantly higher than that in patients with hepatocellular carcinoma. The serum level of TGF-α is helpful to the diagnosis and differential diagnosis of hepatocellular carcinoma, but its effect is better than that of AFP.