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目的观察干扰素 -α治疗重症轮状病毒肠炎的临床效果。方法将 14 2例重症轮状病毒肠炎患者随机分为两组。对照组 :应用病毒唑 ,10～ 15 mg/ (kg· d) ,每日静脉滴注 ,连用 5天。治疗组 :应用干扰素 -α 2万 U / (kg· d) ,1次 / d,肌肉注射 ,连用 3天。其他治疗方法两组相同。结果治疗组 72例 ,12小时内治疗者 2 6例 ,总有效 2 6例 (10 0 % ) ,其中显效 2 4例 (92 .3 % ) ;12～ 2 4小时治疗者 2 4例 ,总有效 2 4例 (10 0 % ) ,其中显效 17例 (70 .8% ) ;2 5～ 48小时治疗者 2 2例 ,总有效 2 2例 (10 0 % ) ,其中显效 9例、占 40 .9%。在显效方面 ,各组间均具有显著性差异 (P<0 .0 5 )。对照组 70例 ,12小时内治疗者 2 3例 ,12～ 2 4小时治疗者 2 8例 ,2 4～ 48小时治疗者 19例 ,均无效。结论干扰素 -α治疗重症轮状病毒肠炎具有极显著效果 ,而且用药越早效果越显著。病毒唑治疗本病无效
Objective To observe the clinical effect of interferon-α in the treatment of severe rotavirus enteritis. Methods A total of 142 patients with severe rotavirus enteritis were randomly divided into two groups. The control group: Ribavirin, 10 ~ 15 mg / (kg · d), daily intravenous drip, once every 5 days. Treatment group: the application of interferon-α 20,000 U / (kg · d), 1 / d, intramuscular injection, once every 3 days. Other treatments are the same for both groups. Results 72 cases of treatment group, 12 cases within 12 hours of treatment of 26 cases, the total effective 26 cases (100%), of which 24 cases (92.3%); 12 ~ 24 hours treatment 24 cases, total Effective in 24 cases (100%), of which markedly effective in 17 cases (70.8%); 25 to 48 hours treatment of 22 cases, the total effective 22 cases (10%), of which 9 cases markedly, accounting for 40 .9%. In terms of effectiveness, there was a significant difference between the groups (P <0.05). There were 70 cases in the control group, 23 cases in 12 hours, 28 cases in 12 to 24 hours and 19 cases in 24 to 48 hours. Conclusion Interferon-α treatment of severe rotavirus enteritis has a very significant effect, and the more effective the more obvious the effect. Ribavirin treatment of the disease is invalid