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目的研究人体胃内细菌数量与胃内pH值的关系,初步探讨胃酸减少是否能引起胃肠道的感染。方法选择66例慢性胃炎患者作为研究对象。胃镜下取胃液测胃液pH值,取胃组织做需氧及厌氧细菌培养,计数胃组织细菌培养数量,检测幽门螺杆菌(helicobacter pylori,Hp)感染情况。检查后随访患者在胃组织培养前后共半年时间内是否服用抑制胃酸药物、有无胃肠道感染的发生及其它相关因素。结果统计学分析结果表明,需氧条件下,人体胃内细菌培养数量随胃内pH值的增高而升高(P=0.000);厌氧条件下,细菌培养数量也随胃内pH值的升高而升高(P=0.001)。患者在胃组织培养前后共半年时间内发生胃肠道感染者8例,大多为胃酸减少或服用抑制胃酸药物的病人。Logistic回归分析表明,胃肠道感染与胃酸减少(P=0.018)相关,而与性别(P=0.513)、年龄(P=0.826)、糖尿病情况(P=0.539)、Hp感染(P=0.196)及免疫增强剂的使用(P=0.341)无关。结论人体胃内细菌培养的数量与胃内pH值呈正比。胃酸减少可能与胃肠道感染关系密切。
Objective To study the relationship between the number of bacteria in the human stomach and the pH in the stomach and to explore whether the decrease of gastric acid can cause the gastrointestinal tract infection. Methods Sixty-six patients with chronic gastritis were selected as the study subjects. Under gastric endoscopy, gastric juice was used to measure the pH value of gastric juice, aerobic and anaerobic bacterial cultures were taken from the stomach tissue, the number of bacterial culture in the stomach tissue was counted, and the infection of helicobacter pylori (Hp) was detected. After the test, patients were followed up for about half a year before and after gastric tissue culture, and whether they took gastric acid drugs, whether gastrointestinal infections occurred or not, and other related factors. Results The results of statistical analysis showed that under aerobic conditions, the number of bacterial cultures in the human stomach increased with increasing intragastric pH (P = 0.000). Under anaerobic conditions, the number of bacterial cultures also increased with increasing intragastric pH High and increased (P = 0.001). In patients with gastrointestinal infections in a total of six months before and after gastric tissue infection in 8 patients, mostly in patients with gastric acid reduction or taking gastric acid suppression drugs. Logistic regression analysis showed that gastrointestinal infections were associated with decreased gastric acid (P = 0.018), but not with gender (P = 0.513), age (P = 0.826), diabetes mellitus (P = 0.539) And the use of immunostimulants (P = 0.341). Conclusion The amount of bacterial culture in the human stomach is proportional to the intragastric pH value. Gastric acid reduction may be closely related to gastrointestinal infections.