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目的本研究着重探讨萎缩性胃炎合并幽门螺杆菌(HP)和血清胃泌素的相关性,探讨萎缩性胃炎癌变的发病机制。方法通过观察慢性浅表性胃炎和萎缩性胃炎血清胃泌素水平以及萎缩性胃炎(B型)合并HP阳性感染组和HP阴性组血清胃泌素水平变化,比较血清胃泌素在各组之间有无统计学意义。结果萎缩性胃炎组血清胃泌素水平明显低于慢性浅表性胃炎组,慢性浅表性胃炎HP阳性组血清胃泌素水平明显高于HP阴性组,且均有显著性差异(P<0.05)。而萎缩性胃炎HP阳性感染组血清胃泌素水平和HP阴性组相比较并无显著性差异(P>0.05)。结论慢性萎缩性胃炎存在低胃泌素血症,HP感染并不能改变萎缩性胃炎的低胃泌素状态,长时间低胃泌素血症是诱导胃粘膜癌变的重要因素之一。
Objective This study focused on the association of atrophic gastritis with Helicobacter pylori (HP) and serum gastrin, and to explore the pathogenesis of atrophic gastritis. Methods The levels of serum gastrin in patients with chronic superficial gastritis and atrophic gastritis were observed. The levels of serum gastrin in patients with atrophic gastritis (type B), HP positive infection group and HP negative group were compared. Is there any statistical significance? Results The level of serum gastrin in atrophic gastritis group was significantly lower than that in chronic superficial gastritis group and the serum gastrin level in chronic superficial gastritis HP group was significantly higher than that in HP negative group (P <0.05) ). Serum gastrin levels in HP-positive atrophic gastritis group were not significantly different from those in HP-negative group (P> 0.05). Conclusion There is hypogastrinmia in chronic atrophic gastritis. HP infection does not change the low gastrin status of atrophic gastritis. Long-term hypoglycemia is one of the important factors in inducing carcinogenesis of gastric mucosa.