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目的 :探讨含铜宫内节育器 (IUD)对女性生殖道衣原体感染的作用。方法 :应用酶免疫测定法检出子宫颈沙眼衣原体阳性患者 5 8例 ,2 1例为置含铜IUD组 ,分别放置含铜表面积为 375mm2 和 2 0 0mm2 的金属环 ;2 4例为药物治疗组 ,用强力霉素或阿奇霉素治疗 ;另 13例未治疗组 ,宫腔内放置不含铜IUD ,以后用酶免疫测定法复查。结果 :放置含铜IUD组沙眼衣原体转阴率为 80 .90 % ,药物治疗组沙眼衣原体转阴率为 91.70 % ,均明显高于对照组 (P <0 .0 0 5 ) ,含铜IUD组转阴率与药物治疗组差异无显著性 (P >0 .0 5 )。结论 :含铜IUD对生殖道沙眼衣原体感染有抑制作用。
Objective: To investigate the effect of copper-containing intrauterine device (IUD) on female genital Chlamydia infection. Methods: Fifty-eight cases of cervical Chlamydia trachomatis-positive patients were detected by enzyme-linked immunosorbent assay (ELISA). Twenty-one patients with copper-containing IUD group were placed on metal rings with a surface area of 375mm2 and 200mm2, respectively. Twenty- Group, with doxycycline or azithromycin treatment; the other 13 cases untreated group, placed intrauterine copper-free IUD, after the enzyme immunoassay for review. Results: The negative rate of Chlamydia trachomatis in the copper-containing IUD group was 80.90%, and the negative rate of Chlamydia trachomatis in the drug-treated group was 91.70%, which were significantly higher than those in the control group (P <0.05) There was no significant difference between the rate of negative conversion and the drug treatment group (P> 0.05). Conclusion: Copper-containing IUD can inhibit genital Chlamydia trachomatis infection.