本文研究了莨菪碱类药物对家兔食管下括约肌(LES)紧张压力的影响,家兔用乌拉坦麻醉后,制作小胃、记录食管下括约肌压力(LESP)和血压变化,切断双侧颈迷走神经,排除迷走神经对LES控制,LESP平均升高39.58±2.76%(P<0.01)n=52,而莨菪碱类药物、酚妥拉明、哌唑嗪均能抑制切断迷走神经后的LES使其LESP降低,抑制强度顺序:哌唑嗪,酚妥拉明、阿托品、山莨菪碱、东莨菪碱、樟柳碱。苯肾上腺素可引起LESP明显高,用莨菪碱类药物,酚妥拉明,哌唑嗪后,再次注射苯肾上腺素其LESP升高作用受到抑制、抑制强度顺序与前述一致,初步证明莨菪碱类药物对LESα型肾上腺素受体具有阻滞作用、 In this paper, we investigated the effect of scopolamine on the tension of the lower esophageal sphincter (LES) in rabbits. After the rabbits were anesthetized with urethane, the small stomach was made and the esophageal sphincter pressure (LESP) and blood pressure were recorded. (P <0.01), n ​​= 52. However, all of the drugs, phentolamine and prazosin, could inhibit the LESP after vagus nerve was cut off to decrease the LESP , Inhibit the intensity of the order: prazosin, phentolamine, atropine, anisodamine, scopolamine, anisodine. Phenylephrine can cause LESP was significantly higher, with hyoscyamine drugs, phentolamine, prazosin, re-injection of phenylephrine increased inhibition of LESP was inhibited, the order of inhibition intensity consistent with the above, preliminary evidence of hyoscyamine Drugs have a blocking effect on LES alpha adrenergic receptors,