通过观察α-苦瓜籽蛋白对体外培养的人胚泡滋养层细胞形态、HCG分泌功能的影响,以及对人蜕膜细胞形态改变,探讨了α-苦瓜籽蛋白抗早孕的细胞学作用机理。0.13,0.50,2.00,8.00 μg/mlα-苦瓜籽蛋白对滋养层细胞形态有不同程度的损伤,时间越长、浓度越大则损伤越重;滋养层细胞分泌HCG功能受到明显抑制,同时对蜕膜细胞也有一定的毒性作用。实验证明:α-苦瓜籽蛋白具有直接损伤滋养层细胞以及毒害蜕膜细胞而达到抗早孕的作用。 By observing the effect of α-bitter gourd seed protein on the morphology of human trophoblast trophoblast cells and the secretion of HCG, as well as the morphological changes of human decidual cells, the cytological mechanism of α-bitter gourd seed protein against early pregnancy was explored. 0.13, 0.50, 2.00, and 8.00 μg/ml α-bitter gourd seed protein had different degrees of damage to the trophoblast cell morphology. The longer the time, the greater the concentration, the more severe the injury; the trophoblast cells secreted HCG function was significantly inhibited. Membrane cells also have some toxic effects. Experiments have shown that α-bitter gourd seed protein has the effect of directly damaging trophoblast cells and poisoning decidual cells to achieve early pregnancy resistance.