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目的:进一步提高甲氧沙林(8-MOP)分散片的稳定性。方法:将8-MOP与β-环糊精(β-CYD)形成包合物,再制备成分散片。与普通分散片相比,通过稳定性试验,判断包合物分散片的体外稳定性。通过体外溶出度测定,考察包合物分散片对溶出度的影响。结果:本包合物的包合率为(96.8±2.4)%(n=3),说明包合物形成较好。稳定性试验表明,包合物分散片对强光的稳定性显著提高,其体外溶出度也有明显增加(P<0.05)。结论:8-MOP/β-CYD包合物分散片比普通8-MOP分散片稳定性更好,溶出速率更高,值得进一步研制。
Objective: To further improve the stability of methoxsalen (8-MOP) dispersible tablets. Methods: The 8-MOP and β-cyclodextrin (β-CYD) form an inclusion complex, and then prepared into dispersible tablets. Compared with the ordinary dispersible tablets, through the stability test, to determine the stability of the inclusion complex dispersible tablets in vitro. Through in vitro dissolution test to investigate the impact of inclusion compound dispersible tablets on dissolution. Results: The inclusion rate of the inclusion complex was (96.8 ± 2.4)% (n = 3), indicating that the inclusion complex formed better. The stability test showed that the stability of the dispersible tablets to light was significantly improved, and its in vitro dissolution rate also increased significantly (P <0.05). CONCLUSION: The 8-MOP / β-CYD inclusion dispersion has better stability and dissolution rate than conventional 8-MOP dispersible tablets, which deserves further research.