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目的观察盐酸羟考酮缓释片(奥施康定)治疗晚期癌症疼痛的临床效果、不良反应及患者生活质量的改善情况。方法 41例中重度疼痛患者给予奥施康定镇痛治疗,初始剂量10mg/12h,根据疼痛情况调整剂量,直至患者无痛或基本无痛。结果 41例中重度癌痛患者,未缓解1例,轻度缓解3例,中度缓解10例,明显缓解20例,完全缓解7例,中度以上缓解率90.2%。治疗前平均KPS评分60.8分,治疗后72.5分,生活质量治疗后较治疗前明显改善(P<0.05)。不良反应主要为便秘13例(31.7%)。结论盐酸羟考酮缓释片能有效控制癌痛,改善生活质量,且不良反应轻微。
Objective To observe the clinical effects, side effects and quality of life of oxycodone hydrochloride sustained release tablets (Oxocodone) in the treatment of advanced cancer pain. Methods Forty-one patients with moderate to severe pain were given oxocampat analgesia. The initial dose was 10 mg / 12 h. The dose was adjusted according to the pain condition until the patient had no pain or almost no pain. Results In 41 patients with moderate to severe cancer pain, there was no remission in 1 case, mild remission in 3 cases, moderate remission in 10 cases, significant remission in 20 cases, complete remission in 7 cases and moderate remission rate of 90.2%. The average KPS score before treatment was 60.8 points, 72.5 points after treatment, and the quality of life was significantly improved after treatment (P <0.05). Adverse reactions mainly constipation in 13 cases (31.7%). Conclusion Oxycodone hydrochloride sustained release tablets can effectively control cancer pain, improve quality of life, and mild adverse reactions.