论文部分内容阅读
1.本文描述了三尖杉酯碱对小鼠L_(1210)腹水瘤细胞超微结构的影响。瘤细胞主要是以“凋落”(Apoptosis)的形式裂解死亡。并观察和讨论了这种坏死细胞的形态变化过程。2.三尖杉酯碱引起瘤细胞有丝分裂减少,从超微结构的变化分析,可能是由于药物引起分裂间期细胞的损伤,从而使进入分裂期的细胞数减少。3.通过观察三尖杉酯碱对瘤细胞超微结构的作用,我们对药物作用的原理进行了讨论,初步认为它可能是直接对核酸的结构与代谢发生作用,但也不能排除对蛋白质代谢的干扰。4.实验组细胞中A型病毒颗粒的减少,可能主要是瘤细胞受到药物的破坏,而间接影响了病毒的正常复制。
1. This article describes the effect of harringtonine on the ultrastructure of mouse L_(1210) ascites tumor cells. The tumor cells are mainly lysed by death in the form of “Apoptosis”. Observed and discussed the morphological changes of this necrotic cell. 2. The harringtonine causes a decrease in the mitosis of tumor cells. The analysis of ultrastructural changes may be due to drug-induced interphase cell damage, resulting in a decrease in the number of cells entering the dissociation phase. 3. By observing the effect of harringtonine on the ultrastructure of tumor cells, we discussed the principle of drug action. It is presumed that it may directly affect the structure and metabolism of nucleic acids, but it cannot exclude the metabolism of proteins. Interference. 4. The reduction of type A virus particles in the cells of the experimental group may be mainly due to the destruction of tumor cells by the drugs, which indirectly affects the normal replication of the virus.