陈××,男性,25岁,住院号160852,病人自述出生后即有全身皮肤黑褐色,以乳头、乳晕及关节伸屈部位为著.一向食欲欠佳,身体亦较瘦弱。常感精神不振,乏力,头晕眼花,但尚能坚持上学,高中毕业后参加轻体力劳动.1979年3月起皮肤色素加深,乏力更明显,并出现右下肢麻木发凉,活动不便.1980年以后左下肢亦出现类似表现以致行走困难.在当地多方治疗无效, Chen × ×, male, 25 years old, hospital number 160852, the patient self-report after birth that the body skin dark brown, with nipple, areola and joint flexion parts for. Has always been poor appetite, the body is also relatively thin. Often feeling sluggish, weak, dizzy, but still able to adhere to school, after high school to participate in light manual work .1979 in March from the skin pigmentation, fatigue more obvious, and the right lower extremity numbness, activity inconvenience. After the lower left leg also appeared similar to the performance of walking difficulties in the local multi-treatment ineffective,