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目的:探讨甘精胰岛素在2型糖尿病患者围手术期的应用效果。方法:将78例围手术期2型糖尿病患者随机分为3组,甘精胰岛素加门冬胰岛素组26例,精蛋白人胰岛素(NPH)加人胰岛素组26例,静脉胰岛素输注组26例。观察3组治疗前后的血糖情况、控制血糖时间、低血糖发生率、胰岛素总量、降血糖平均费用的差异。结果:空腹血糖、午晚餐前血糖、血糖调整时间、降糖费用方面,甘精胰岛素组和精蛋白胰岛素加人胰岛素组与静脉胰岛素均有统计学意义;三餐后2小时血糖:甘精胰岛素组和精蛋白胰岛素加人胰岛素组无统计学意义;空腹血糖、午晚餐前血糖、三餐后2小时血糖、睡前血糖:甘精胰岛素组、精蛋白胰岛素加人胰岛素组与静脉胰岛素均有统计学意义。结论:对2型糖尿病围手术期患者应用甘精胰岛素,其血糖达标情况明显优于NPH皮下注射、静脉胰岛素输注组,适宜在无胰岛素泵的基层医院应用。
Objective: To investigate the effect of glargine in patients with type 2 diabetes during perioperative period. Methods: Totally 78 patients with perioperative type 2 diabetes mellitus were randomly divided into 3 groups: 26 patients with insulin glargine and insulin aspart, 26 patients with NPH plus insulin and 26 patients with intravenous insulin infusion . 3 groups before and after treatment to observe the blood glucose, blood glucose control time, the incidence of hypoglycemia, total insulin, the average cost of hypoglycemic differences. Results: Fasting blood glucose, fasting blood glucose before lunch and dinner, blood glucose adjustment time, hypoglycemic expenses, insulin glargine group and protamine insulin plus insulin group and intravenous insulin were statistically significant; 2 hours after three meals of blood glucose: insulin glargine Fasting blood glucose, fasting blood glucose, fasting blood glucose before lunch and two hours, fasting blood glucose after three meals, blood glucose before going to sleep: insulin glargine group, insulin plus insulin group and intravenous insulin were Statistical significance. Conclusion: The application of insulin glargine to perioperative patients with type 2 diabetes mellitus is superior to NPH subcutaneous injection and intravenous insulin infusion group, which is suitable for the primary hospital without insulin pump.