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N-酰基磺酰胺在硼烷-二甲硫醚(8 eq)作用下,THF中回流15~120 min,可被还原为相应的N-烷基磺酰胺,14例收率48%~100%。芳环上带有吸电子基团收率较低,被还原的羰基立体位阻大,收率较低。
N-acylsulfonamide can be reduced to the corresponding N-alkylsulfonamides by refluxing in THF for 15-120 min under the action of borane-dimethylsulfide (8 eq). The yields of 14 N-acylsulfonamides are 48% -100% . The aromatic ring with a lower electron-withdrawing group yield, reduction of carbonyl steric hindrance, low yield.