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目的观察腹腔镜保守性手术联合甲氨蝶呤局部系膜注射治疗异位妊娠(PEP)近远期疗效。方法 60例异位妊娠患者,随机分为三组,即不使用组、术前使用组、术中使用组,各20例,不使用组单纯的采用腹腔镜保守性手术,术前使用组在手术之前采用甲氨蝶呤治疗,术中使用组在腹腔镜下保守性治疗的基础上,术中联合甲氨蝶呤治疗,并进行随访,观察三组患者的综合疗效。结果在观察三组患者的综合疗效中,存在一定的差异性。其中,术中使用组在腹腔镜下保守性治疗的基础上,患者的人绒毛膜促性腺激素(β-HCG)下降率为(54.8±6.2)%、下降至正常所需时间为(10.02±2.04)d,均优于其他两组,差异具有统计学意义(P<0.05)。结论在治疗异位妊娠中,通过采用在腹腔镜下保守性手术联合甲氨蝶呤局部系膜注射的方式,能有效的促进β-HCG下降率,在临床中具有一定的效果,是一种理想的临床手术方式,值得临床推广。
Objective To observe the short-term and long-term effects of laparoscopic conservative surgery combined with methotrexate local mesangial injection in the treatment of ectopic pregnancy (PEP). Methods Sixty patients with ectopic pregnancy were randomly divided into three groups: untreated group, preoperative group, intraoperative group, each of 20 cases, without laparoscopic conservative surgery alone, preoperative group Methotrexate treatment before surgery, intraoperative use group in laparoscopic conservative treatment based on intraoperative and methotrexate treatment, and were followed up to observe the combined effect of three groups of patients. Results in the observation of three groups of patients in the comprehensive efficacy, there are some differences. Among them, the intraoperative use of laparoscopic conservative treatment based on the patient’s human chorionic gonadotropin (β-HCG) decreased (54.8 ± 6.2)%, down to normal time required for (10.02 ± 2.04) d were better than the other two groups, the difference was statistically significant (P <0.05). Conclusion In the treatment of ectopic pregnancy, by the use of laparoscopic conservative surgery combined with methotrexate topical mesangial injection, can effectively promote the rate of decline in β-HCG, has a certain clinical effect, is a The ideal clinical operation, it is worth clinical promotion.