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目的:观察浅表肿块内注射纳科思(TNF-α变构体)联合放疗的疗效及患者生活质量的改善情况。方法:将收集的46例恶性肿瘤的浅表肿块分为甲、乙两组,进行回顾性分析。甲组为浅表肿块内注射纳科思联合放疗,乙组为单纯放疗组。两组放疗方法、剂量相同。结果:46例有2例因纳科思严重过敏而退出治疗,可供临床疗效分析者44例,其中甲组27例,乙组17例。放疗至40G y及放疗结束时,甲组有效率分别为81.48%、96.30%,高于乙组52.94%及88.24%(40G y时比较P<0.05,放疗结束时比较P>0.05);放疗后患者行为状态KPS评分甲组明显高于乙组(P<0.05)。结论:在治疗恶性肿瘤的浅表肿块时,瘤内注射纳科思联合放疗,能提高放疗的敏感性和近期疗效,并能提高患者生活质量。
OBJECTIVE: To observe the effect of intratumoral injection of nalcosine (TNF-α allosteric) combined with radiotherapy on the improvement of quality of life of patients. Methods: The superficial lumps of 46 cases of malignant tumors were divided into two groups, A and B, for retrospective analysis. In group A, superficial intratumoral injection of Narcox combined with radiotherapy was performed, and group B was treated with radiotherapy alone. The two groups of radiotherapy methods and doses were the same. RESULTS: Two out of 46 patients withdrew from treatment due to severe nausea allergy. There were 44 cases available for clinical efficacy analysis, including 27 cases in group A and 17 cases in group B. At the end of radiotherapy to 40G y and radiotherapy, the effective rates in group A were 81.48% and 96.30%, respectively, higher than those in group B 52.94% and 88.24% (P<0.05 at 40G y, P>0.05 at the end of radiotherapy); after radiotherapy The KPS score of patients’ behavioral status in group A was significantly higher than that in group B (P<0.05). Conclusion: In the treatment of superficial tumors of malignant tumors, intratumoral injection of nanocosmetic combined with radiotherapy can improve the sensitivity and short-term efficacy of radiotherapy, and can improve the quality of life of patients.