论文部分内容阅读
目的:观察通腹益气汤对脓毒症患者胃肠功能障碍的临床疗效,并探讨其干预机制。方法:将180例脓毒症胃肠功能障碍患者随机分为对照组89例,治疗组91例。对照组给予西医常规治疗,治疗组在上述治疗的基础上加用通腹益气汤治疗。20天后观察患者血浆肿瘤坏死因子α(TNFα)、脑钠肽(BNP)、血浆降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-10(IL-10)的水平变化,并进行疗效比较。结果:2组治疗后血浆TNFα、BNP、PCT、CRP、IL-10水平与本组治疗前比较差异有统计学意义(P<0.05);治疗组治疗后血浆TNFα、BNP、PCT、CRP、IL-10水平与对照组比较差异有统计学意义(P<0.05)。结论:通腹益气汤可以明显降低患者血浆TNFα、BNP、PCT、CRP、IL-10水平,保护胃肠黏膜屏障,促进血液循环,改善患者胃肠功能障碍。
Objective: To observe the clinical effect of Tongbian Yiqi Decoction on gastrointestinal dysfunction in patients with sepsis and to explore its intervention mechanism. Methods: 180 patients with gastrointestinal dysfunction of sepsis were randomly divided into control group (n = 89) and treatment group (n = 91). The control group was given routine treatment of Western medicine, and the treatment group was treated with Tongbian Yiqi Decoction on the basis of the above treatment. Twenty days later, the levels of tumor necrosis factor alpha (TNFα), brain natriuretic peptide (BNP), plasma procalcitonin (PCT), C-reactive protein (CRP) and interleukin-10 (IL-10) And compare the efficacy. Results: The levels of plasma TNFα, BNP, PCT, CRP and IL-10 in the two groups after treatment were significantly different from those before treatment (P <0.05) -10 levels compared with the control group, the difference was statistically significant (P <0.05). Conclusion: Tongxu Yiqi Decoction can significantly reduce the level of plasma TNFα, BNP, PCT, CRP and IL-10, protect the gastrointestinal mucosal barrier, promote blood circulation and improve gastrointestinal dysfunction in patients.