近年以大鼠为观察对象的一系列实验所见表明生殖功能老化始于中年期的丘脑下部功能改变。丘脑下部的生物钟与脉冲发生器出现昼夜周期节律改变导致神经内分泌和内分泌的释放节律和释放量发生改变。这些改变进行性发展,直至生殖周期与生殖能力丧失。 In recent years, a series of experiments observed in rats showed that reproductive aging began in middle-aged subthalamic functional changes. Changes in circadian rhythms of the circadian clock and pulse generator in the hypothalamus lead to changes in the release and release of neuroendocrine and endocrine hormones. These changes progressively progress until the reproductive cycle and fertility are lost.