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目的 探讨宫颈癌低氧放疗的临床应用价值 .方法 1995 - 0 2 / 1998- 0 6 ,80例宫颈癌随机分为低氧放疗组和常规放疗组各 40例 .两组均采用腔内照射与外照射相结合的方法 .腔内照射剂量 40～ 5 0 Gy/ 8～ 10 wk,体外照射剂量 5 0Gy/ 6～ 8wk.低氧组佩戴低氧呼吸装置 (相当于呼吸含氧量为 10 .5 %的低氧气体 ) .结果 低氧组和常规放射治疗组的肿瘤完全缓解 (CR)、部分缓解 (PR)、无效应 (NR)分别为6 0 .0 %和 6 2 .5 % ,35 .0 %和 32 .5 % ,5 .0 %和 5 .0 % ;直肠炎、膀胱炎、阴道粘连、厌食、恶心或呕吐、腹泻的发生率分别为2 .5 %和 15 .0 % ,0 %和 7.5 % ,12 .5 %和 45 .0 % ,5 .0 %和32 .5 % ,2 .5 %和 12 .5 % ,37.5 %和 45 .1% ;白细胞数变化分别为 (3.9± 0 .8)× 10 9· L- 1 和 (2 .8± 10 .7)× 10 9· L- 1 .结论 低氧放疗可减轻宫颈癌患者的放疗副作用和降低并发症的发生率 .
Objective To investigate the clinical value of hypoxic radiotherapy for cervical cancer.Methods Between 1995 and 2002, 80 cases of cervical cancer were randomly divided into hypoxia radiotherapy group and conventional radiotherapy group, 40 cases in each group, The combination of external irradiation and intracavitary irradiation dose 40 ~ 500 Gy / 8 ~ 10 wk, external dose 50 Gy / 6 ~ 8wk. Hypoxia group wearing hypoxia breathing apparatus (equivalent to respiratory oxygen content of 10. 5% hypoxia) .Results The complete remission (CR), partial remission (PR) and no effect (NR) of tumor in hypoxia group and conventional radiotherapy group were 60.0% and 62.5% 35.0% and 32.5%, 5.0% and 5.0% respectively. The rates of proctitis, cystitis, vaginal adhesions, anorexia, nausea or vomiting and diarrhea were 2.5% and 15.0% , 0% and 7.5%, 12.5% and 45.0%, 5.0% and 32.5%, 2.5% and 12.5%, 37.5% and 45.1% (3.9 ± 0.8) × 10 9 · L -1 and (2. 8 ± 10 7) × 10 9 · L -1, respectively.Conclusion Hypoxic radiotherapy can reduce the radiotherapy side effects and reduce the incidence of complications in patients with cervical cancer Rate.