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[目的]探讨前列腺特异性抗原(PSA)在前列腺癌中的诊断作用。[方法]回顾性分析PSA水平正常患者3637例及PSA异常患者1259例,计算阳性、阴性率,结合文献进行分析。[结果]PSA>4.0ng/ml中前列腺癌135例,阳性率10.86%。PSA诊断前列腺癌的敏感度为89.40%,特异性为76.57%。不同年龄、不同前列腺体积患者的前列腺癌检出率有统计学差异。[结论]PSA是诊断前列腺癌的肿瘤标志物,但特异性不高。
[Objective] To investigate the diagnostic value of prostate-specific antigen (PSA) in prostate cancer. [Methods] A retrospective analysis of 3637 patients with normal PSA levels and 1259 patients with abnormal PSA were performed. The positive and negative rates were calculated and analyzed in combination with the literature. [Results] There were 135 cases of prostate cancer with PSA> 4.0ng / ml, the positive rate was 10.86%. PSA sensitivity of prostate cancer was 89.40%, specificity was 76.57%. Different age, different prostate volume in patients with prostate cancer detection rates were statistically different. [Conclusion] PSA is a tumor marker for the diagnosis of prostate cancer, but its specificity is not high.