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目的:比较广东地区不同人群中血清炎症因子和牙周指标的差异,为牙周炎与冠心病相关性研究提供一定的实验依据。方法:对44例伴有冠心病的牙周炎患者,48例慢性牙周炎患者和45名健康志愿者血清超敏C反应蛋白(hs-CRP)水平进行检测,并对伴有冠心病的牙周炎患者以及慢性牙周炎患者进行牙周检查,记录牙周临床指标(包括牙周袋深度,附着丧失以及探诊出血指数)。结果:伴有冠心病的牙周炎组hs-CRP显著高于慢性牙周炎组和健康对照组(P<0.05),慢性牙周炎组的hs-CRP水平又显著高于健康对照组(P<0.05)。伴有冠心病的牙周炎组的牙周探诊深度、附着丧失水平和龈沟出血指数高于慢性牙周炎组(P<0.05)。结论:牙周炎可以引起hs-CRP水平升高,冠心病可能会加重牙周炎水平。
Objective: To compare the differences of serum inflammatory factors and periodontal indices in different populations in Guangdong, and to provide some experimental evidences for the study of the correlation between periodontitis and coronary heart disease. Methods: Serum hs-CRP levels were measured in 44 patients with periodontitis with coronary heart disease, 48 patients with chronic periodontitis and 45 healthy volunteers. The levels of serum hs-CRP in patients with coronary heart disease Periodontitis patients and patients with chronic periodontitis. Periodontal clinical parameters (including the depth of pocket, attachment loss and exploration bleeding) were recorded. Results: The hs-CRP level in periodontitis group with coronary heart disease was significantly higher than that in chronic periodontitis group and healthy control group (P <0.05). The hs-CRP level in chronic periodontitis group was significantly higher than that in healthy control group P <0.05). The periodontal exploration depth, attachment loss and sulcus bleeding index in periodontitis group with coronary heart disease were higher than those in chronic periodontitis group (P <0.05). Conclusion: Periodontitis can cause the increase of hs-CRP level, and coronary heart disease may aggravate periodontitis.