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对 4 2例大肠癌患者手术前后血清中癌胚抗原 (Carinoembryonle Antigen ,CEA)及可溶性白介素 - 2受体 (Solubleinter leukin- 2 receptor,SIL - 2 R)的检测结果显示 ,术前血清 CEA及 SIL - 2 R均高于对照组 (P <0 .0 1) ,且随 Duke′s分期增高而升高。术后血清 CEA较 SIL- 2 R下降快。但 SIL- 2 R在术后 10 d内反升高 ,尤其是 6例 Duke′s D期患者更明显 ,可能与肿瘤本身转移及手术对机体免疫功能抑制有关。CEA及 SIL- 2 R与肿瘤的病理类型无关。提示 ,术后定期联合监测 CEA及 SIL- 2 R可为临床观察肿瘤患者的病情变化、严重程度、监测疗效及判断预后提供依据 ,及早发现术后复发病人。
Serum levels of CEA and SIL - 2R in 42 patients with colorectal cancer before and after operation showed that preoperative serum CEA and SIL - 2 R were higher than those in the control group (P <0.01), and increased with Duke’s staging. Postoperative serum CEA decreased faster than SIL-2R. However, SIL-2 R increased inversely within 10 days after operation, especially in 6 patients with Duke’s D stage. This may be related to tumor metastasis and the suppression of immune function. CEA and SIL-2 R have nothing to do with the pathological type of tumor. It is suggested that the regular combined monitoring of CEA and SIL-2 R after surgery can provide a basis for clinical observation of tumor patients’ condition, severity, monitoring efficacy and prognosis, and early detection of postoperative recurrence.