Climate feedbacks have been usually estimated using changes in radiative effects associated with increasedglobal-mean surface temperature. Feedback uncertainties, however, are not only functions of global-mean surface temperature increase. In projections by global climate models, it has been demonstrated that the geographical variation of sea surface temperature change brings significant uncertainties into atmospheric circulation and precipitation responses at regional scales. Here we show that the spatial patt of surface warming is a major contributor to uncertainty in the combined water vapour-lapse rate feedback. This is demonstrated by computing the global-mean radiative effects of changes in air temperature and relative humidity simulated by 31 climate models using a methodology based on radiative kels. Our results highlight the important contribution of regional climate change to the uncertainty in climate feedbacks, and identify the regions of the world where constraining surface warming patts would be most effective for higher skill of climate projections.