目的探讨分化型甲状腺癌(DTC)甲状腺清除术后血清甲状腺球蛋白(Tg)联合131I全身显像(131I-WBS),为判定甲状腺癌的复发及转移提供参考依据。方法 56例DTC患者,甲状腺全切或次全切术后4~6周,均行131I清除残余甲状腺治疗,3~6个月后重复治疗,治疗前停用甲状腺激素3~6周,同时忌碘饮食,治疗中检测血清Tg和口服碘化钠(131I)治疗剂量3.70~7.40 GBq后5~7天行131I-WBS。结果在首次清除残留甲状腺组织治疗时,显像发现淋巴结、肺及骨转移8例,其余转移灶于3~6个月后二次治疗时发现,有11例DTC患者(19.6%)Tg测定在正常范围,而131I-WBS出现转移灶;有7例患者(12.5%)Tg测定异常,而131I-WBS正常。结论 Tg测定和131I-WBS可作为诊断DTC术后复发及转移的重要指标,二者应联合应用、互相补充,具有重要的临床价值。 Objective To investigate the relationship between serum thyroglobulin (Tg) and 131I whole body scintigraphy (131I-WBS) in patients with differentiated thyroid cancer (DTC) after thyroidectomy and provide a reference for judging the recurrence and metastasis of thyroid cancer. Methods Fifty-six patients with DTC undergoing total thyroidectomy or 4 ~ 6 weeks after subtotal resection were treated with 131I to remove residual thyroid, 3 to 6 months after treatment, thyroid hormone was stopped for 3 to 6 weeks before treatment, Iodine diet, serum Tg measured during treatment and oral 131I-WBS were administered 5-7 days after oral administration of sodium iodide (131I) at doses ranging from 3.70 to 7.40 GBq. Results In the first removal of residual thyroid tissue, imaging showed lymph node, lung and bone metastases in 8 cases, the remaining metastases in 3 to 6 months after the second treatment found that 11 cases of DTC (19.6%) Tg measured in Normal range, and 131I-WBS metastases; 7 patients (12.5%) Tg abnormalities, and 131I-WBS normal. Conclusion The determination of TgI and 131I-WBS can be used as an important index to diagnose the recurrence and metastasis of DTC. The combination of them should be combined with each other to complement each other and have important clinical value.