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目的:通过对小儿肺部感染性疾病患儿血浆中D-二聚体(D-dimer,D-D)的检测,探讨该指标与小儿肺部感染性疾病的关系及意义,指导临床治疗。方法:对300例住院肺部感染性疾病患儿检测血浆中D-二聚体水平,与健康儿童血浆中D二聚体水平进行对比。结果:小儿肺部感染性疾病患儿血浆中D-二聚体水平明显高于对照组,其临床表现与血浆中D-二聚体水平呈明显正相关。结论:D-二聚体检测提示凝血及纤溶的异常在肺部炎性疾病中起重要作用[1],可以作为重症肺炎血液高凝状态的检测指标。
Objective: To investigate the relationship between D-dimer and D-D in children with pulmonary infectious diseases and its clinical significance. Methods: Plasma levels of D-dimer were measured in 300 hospitalized children with pulmonary infectious diseases and compared with plasma D-dimer level in healthy children. Results: The plasma levels of D-dimer in children with pulmonary infectious diseases were significantly higher than those in the control group, and the clinical manifestations were positively correlated with the plasma D-dimer levels. CONCLUSIONS: D-dimer testing suggests that coagulation and fibrinolytic abnormalities play an important role in inflammatory diseases of the lungs [1] and can be used as a predictor of blood hypercoagulability in severe pneumonia.