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目的 :探讨CD4 4v6基因在不同乳腺组织的表达及其与乳腺癌淋巴结转移的关系。方法 :采用免疫组化S -P法对 113例不同乳腺组织进行CD4 4v6表达的研究。结果 :CD4 4v6阳性表达率在乳腺癌组织 (96 7% )明显高于乳腺良性肿瘤 (5 0 0 % )和正常乳腺组织 (13 3% ) (P <0 0 1) ;CD4 4v6表达强阳性在淋巴结转移组 (92 5 % )明显高于无淋巴结转移组 (30 0 % ) (P <0 0 5 ) ,但淋巴结转移灶 (2 2 2 % )明显低于原发癌灶 (10 0 % ) (P <0 0 5 )。结论 :CD4 4v6基因高表达可作为判断乳腺癌具有转移倾向的临床参考指标。乳腺癌细胞CD4 4v6表达量增高可能是转移发生之前的事件。
Objective: To investigate the expression of CD4 4v6 gene in different breast tissues and its relationship with lymph node metastasis in breast cancer. Methods: The expression of CD4 4v6 in 113 cases of breast tissue was studied by immunohistochemical S-P method. Results: The positive rate of CD4 4v6 expression in breast cancer tissues (96 7%) was significantly higher than that of benign breast tumors (500%) and normal breast tissues (13 3%) (P <0 01); CD4 4v6 expression was strongly positive In the lymph node metastasis group (92.5%) was significantly higher than that in the no lymph node metastasis group (30%) (P <0. 05), but lymph node metastases (22.22%) were significantly lower than the primary tumor (10.0% ) (P < 0 0 5 ). Conclusion: The high expression of CD4 4v6 gene can be used as a clinical reference index to judge the metastasis tendency of breast cancer. Increased expression of CD4 4v6 in breast cancer cells may be an event prior to metastasis.